2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel
  5. Calcium Channel Modulator

Calcium Channel Modulator

Calcium Channel Isoform Comparison

Calcium Channel Modulators (18):

Cat. No. Product Name Effect Purity
  • HY-N0283
    Diacerein
    		Modulator 98.78%
    Diacerein (Diacerhein), an orally active anthraquinone, reduces production of IL-1 converting enzyme then inhibits the activation of IL-1β by related downstream signaling. Diacerein is an anti-inflammatory and anti-rheumatic drug. Diacerein can relieve bronchospasm and control airway inflammation in asthmatic mice. Diacerein has the potential for slow acting drug in osteoarthritis (SYSADOA) research.
  • HY-116330A
    Hyperforin dicyclohexylammonium salt
    		Modulator 99.52%
    Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
  • HY-W074890
    Palmitoylglycine
    		Modulator 99.74%
    Palmitoylglycine (N-palmitoyl glycine), an endogenous lipid that acts as a modulator of calcium influx and nitric oxide () production in sensory neurons. Palmitoylglycine is linked to an increased risk of Background Brugada syndrome (BrS) and interacts with BrS-associated proteins, demonstrating moderate binding affinities for DCC, CR1, CTSB, NAAA, DEFB1, EPHA1, IGF1/IGFBP3/ALS, and LTA.
  • HY-N6694
    4-Bromo A23187
    		Modulator ≥99.0%
    4-Bromo A23187 is a halogenated analog of the highly selective calcium ionophore A-23187. 4-Bromo A23187, a calcium modulator, induces apoptosis in different cells, including HL-60 cells.
  • HY-162566
    REM127
    		Modulator ≥98.0%
    REM127 is a small molecule compound capable of modulating calcium homeostasis in cells and possesses neuroprotective effects. REM127 can restore the calcium homeostasis imbalance in cellular models caused by pathological accumulation of tau protein. REM127 can efficiently cross the blood-brain barrier, and it has the potential to rescue synaptic and cognitive deficits in Alzheimer's disease animal models, as well as to slow down the progression of amyloid-beta and tau protein pathologies. REM127 can be used for research in neurodegenerative diseases.
  • HY-N1369R
    Menthol (Standard)
    		Modulator
    Menthol (Standard) is the analytical standard of Menthol. This product is intended for research and analytical applications. Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes. Menthol also improves oral nicotine rejection in mice.
  • HY-P3710
    Ser-Ala-alloresact
    		Modulator
    Ser-Ala-alloresact is a sperm activating peptide (SAP). The peptides released from eggs of marine invertebrates play a central role in fertilization.
  • HY-116330
    Hyperforin
    		Modulator
    Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels and triggers adipose tissue thermogenesis via the Dlat-AMPK signaling axis to suppress obesity. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
  • HY-E70197A
    Calpain-1, Human Erythrocyte
    		Modulator
    Calpain-1, Human Erythrocyte is an intracellular Ca2+-regulated cysteine protease. Calpain-1, Human Erythrocyte exhibits neuroprotective effect.
  • HY-164803
    CBD3063
    		Modulator
    CBD3063 is a selective modulator of collapsin response mediator protein 2 (CRMP2). CBD3063 uncouples Cav2.2 from CRMP2. CBD3063 reverses neuropathic and inflammatory pain by reducing membrane expression of CaV2.2.
  • HY-Q40876
    BBT
    		Modulator 99.71%
    BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753))-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway.
  • HY-142117
    Adenophostin A
    		Modulator
    Adenophostin A is a potent inositol triphosphate (IP3) receptor agonist, which binds to IP3 receptors with high affinity and effectively stimulates the release of calcium ions (Ca2+).
  • HY-116330AR
    Hyperforin dicyclohexylammonium salt (Standard)
    		Modulator
    Hyperforin (dicyclohexylammonium salt) (Standard) is the analytical standard of Hyperforin (dicyclohexylammonium salt). This product is intended for research and analytical applications. Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model.
  • HY-N1369S1
    Menthol-d2
    		Modulator
    Menthol-d2 is deuterated labeled trans-2,cis-6-Nonadienal (HY-W127515). Trans-2, cis-6-NonadienalIt is an organic compound belonging to aldehydes. It has a strong, pungent smell and is commonly found in a variety of foods, including fruits and vegetables. Trans-2, cis-6-NonadienalIt has a variety of applications in the flavor and fragrance industry, especially as a fragrance agent in products such as perfume, cologne and air fresheners. In addition, it can also be used as an intermediate in the synthesis of various chemicals and drugs.
  • HY-120411
    Sadopine
    		Modulator
    Sadopine is an allosteric modulator for dihydropyridine receptor ((-)Sadopine as positive allosteric modulator and (+)Sadopine as negative allosteric modulator). Sadopine interacts with dihydropyridine (DHP)-sensitive L-type calcium channels.
  • HY-149779
    RyR2 stabilizer-1
    		Modulator
    RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias.
  • HY-P0268
    Myomodulin
    		Modulator
    Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
  • HY-U00135
    Calcium channel-modulator-1
    		Modulator 98.77%
    Calcium channel-modulator-1 is a calcium channel modulator; blocks aortic contraction with an IC50 of 0.8 μM.